On this page, you can find a small sample of the many clinical studies carried out on the most important active ingredients in the Beauty Reset formula. This formula is a proprietary blend, so information on how the synergy between each ingredient works is reserved.

Hydrolyzed Collagen Peptides

Clinical study #1

Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis

© 2021 the International Society of Dermatology.

Clinical study #2

Bioactive Collagen Peptides® VERISOL®

Clinical studies show efficacy of Bioactive Collagen Peptides® VERISOL®

Collagen is the major structural component of skin, comprising about 80% of its dry weight. Skin properties are known to be affected by endogenous and environmental factors including aging, ultraviolet radiation, hormones, and nutrition. VERISOL® can stimulate skin metabolism and counteract the loss of collagenous extracellular matrix from the inside. Consumers who ingest the natural Bioactive Collagen Peptides® VERISOL® specifically optimized for beauty

applications can experience noticeably firmer and smoother skin with fewer wrinkles. The positive effect of VERISOL® also shows improved skin surface structure, reduced cellulite, and faster nail growth with reportedly fewer fingernail chippings. VERISOL® and the associated benefits are available from different raw material sources to meet diverse consumer demands best. VERISOL® is produced from bovine raw materials.

Orally applied, VERISOL® systematically affects the collagen metabolism in the dermis rather than just reaching the outer layers of the skin as with creams and other topical products.

Mode of Action

The specific peptides of VERISOL® are recognized by fibroblast cells in the dermal layer of the skin as collagen fragments like those resulting from catabolic activities. Therefore, they are stimulated to increase their collagen metabolism to counterbalance actual collagen degradation in the dermis. The result is a considerably higher production of dermal collagen and overall extracellular matrix, replacing what is lost through aging and environmental influences.

Significant improvement in skin health

VERISOL® consists of special collagen peptides – important components for supporting healthy skin. Administered orally, VERISOL® influences the skin’s collagen metabolism directly from the inside. It increases skin moisture and delays the formation of wrinkles. Several scientific experiments investigated the potential of VERISOL® .

Higher skin elasticity1

The first study with 69 women between 35 and 55 revealed that VERISOL® leads to significantly higher skin elasticity – up to 15% – compared to placebo treatment. This effect could be measured after just 4 weeks of

Proksch et al. (2014) Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a Double-Blind, Placebo-Controlled Study.
Skin Pharmacol Physiol, 27:47-55.

treatment and continued after 8 weeks of oral VERISOL® administration. Another 4 weeks after the last intake of the product, VERISOL® skin elasticity levels than in the placebo-treated group.

1-Oral Supplementation of Specific Collagen Peptides Has Beneficial Effects on Human Skin Physiology: A Double-Blind, Placebo-Controlled Study.
Proksch E., Segger D., Degwert J., Schunck M., Zague V., Oesser S. Skin Pharmacol Physiology, August 2013

Reduction in wrinkles2

The second study with more than 100 women between 45 and 65 shows that oral administration of VERISOL® (2.5 g/day) significantly reduces wrinkles after 4 weeks and leads to a significantly higher skin procollagen concentration.

Proksch et al. (2014). oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis. Skin Pharmacol Physiol, 27:113-119.

2-Oral Intake of Specific Bioactive Collagen Peptides Reduces Skin Wrinkles and Increases Dermal Matrix Synthesis. Proksch E., Schunck M., Zague V., Segger D., Degwert J., Oesser S. Skin Pharmacol Physiology, December 2013

Improved skin surface structure and decreased cellulite

About 85% of the global female adult population is affected by cellulite (the orange peel texture of skin). Cellulite is a beauty aspect, not a disease, but many women suffer from this beauty flaw. Cellulite is mainly caused by dermal matrix disturbances, in combination with excess subcutaneous fat bulging into the dermis and excess interstitial fluid.

VERISOL® supplementation has beneficial effects on the dermal extracellular matrix of the skin and can help decrease cellulite. Contrary to current cellulite supplements that mainly address the aspects of excessive fat or microcirculation/drainage, VERISOL® directly stimulates the extracellular matrix formation in the skin.

Significant decrease in cellulite score3

A double-blind, randomized, placebo-controlled study with 105 women between 25 and 50 shows that the daily oral intake of 2.5g VERISOL ® significantly decreases the cellulite score. The effect was measured after 3 and 6 months of supplementation. VERISOL ® has a beneficial effect on skin’s extracellular matrix and restores the normal structure of the dermis and subcutaneous tissue. VERISOL ® supplementation also reduced the waviness of the skin, with initial results visible after 3 months and more pronounced after 6 months. With a daily dose of 2.5g VERISOL ® the appearance of the cellulite in women with a BMI < 25 was significantly reduced.

3-JOURNAL OF MEDICINAL FOOD, J Med Food 00 (0) 2015, 1–9, DOI: 10.1089/jmf.2015.0022, Dietary Supplementation with Specific Collagen Peptides Has a Body Mass Index-Dependent Beneficial Effect on Cellulite Morphology

Michael Schunck, 1 Vivian Zague, 2 Steffen Oesser, 1 Ehrhardt Proksch, 3
As part of the study, changes in dermal density were investigated. The two ultrasound scans show side by side the skin of a participant in the placebo group compared to the skin of a participant from the group. The increase in elastin and collagen is clearly visible.
Colors represent the intensity strength of the acoustic response from the skin, thus skin density – mainly collagen. Dark/green color indicates low intensity, yellow/bright color indicates high intensity.

Promoting hair support4

A randomized, placebo-controlled study investigated the effects of VERISOL® on hair thickness. The study was conducted on 44 women between 39 and 75, who were supplemented with 2.5g VERISOL® daily or a placebo for 16 weeks. The use of VERISOL® led to a statistically significant increase in hair thickness. In contrast, a slight decrease was observed in the placebo group, confirming the benefits of VERISOL® “for improved hair structure.”

This is the first published, peer-reviewed study to clearly demonstrate a positive effect of collagen supplementation on hair structure, a key aspect of healthy hair appearance.

4-Oesser (2020). The oral intake of specific Bioactive Collagen Peptides has a positive effect on hair thickness. Nutrafoods, 1:134-138.

Promoting fingernail growth and health5

For many women, well-groomed fingernails are an inseparable part of an attractive appearance. But many women suffer from cracked or chipped nails, nail peeling, and nail roughness. The Bioactive Collagen Peptides (BCP®) VERISOL® can help to improve fingernail growth and health.
The different positive effects of VERISOL® are shown in a recent study. The study shows a decrease in cracked and/or chipped nails after 2 months of treatment,
reaching a decrease of 42% after 6 months. Compared to the control group, the nail growth speed increased. VERISOL® led to a statistically significant improvement in nail growth after 3 months of treatment. At the same time, there’s a notable improvement in nail peeling and decreased nail edge irregularity. 80% of the patients were completely satisfied with VERISOL® treatment. 75% of the women perceived their nails as longer, and 71% said their nails grew faster and became longer.

5-Hexsel D, Zague V, Schunck M, Siega C, Camozzato FO, Oesser S. Oral supplementation with specific bioactive collagen peptides improves nail growth and reduces symptoms of brittle nails. J Cosmet Dermatol. 2017;00:1–7.

S-Acetyl L-Glutathione

Clinical study #3

Oral Administration of S-acetyl-glutathione: Impact on the Levels of Glutathione in Plasma and in Erythrocytes

International Journal of Clinical Nutrition & Dietetics Volume 4 (2018).

Other relevant sources of information about Vaily® Beauty Reset's active ingredients

8 Ways to Boost Glutathione

S-Acetyl L-Glutathione (Orally)

Glutathione – Uses, Side Effects, and More

Glutathione: The Mother of All Antioxidants